Malaria-immune human sera were tested for their ability to affect the infectivity of Plasmodium falciparum gametocytes
to Anopheles stephensi mosquitoes. Transmission-reducing effects of the sera were associated with the presence of
antibodies to the gamete surface protein, Pfs230. Enhancement of transmission, manifest as elevated numbers of oocysts
relative to controls, was observed for a number of sera, but was not found to be associated with antibodies against Pfs230.
These results confirm that Pfs230 is a possible candidate for inclusion in a transmission-blocking malaria vaccine.
