Introduction. Pithecellobiumdulce is a legume native to tropical America that producesedible arils which can be white or red. The plant is also grownin Asia and, to date, predominantly fruits produced in Asia havebeen the subject of scientific studies. We studied white and redarils produced in America. Materials and methods. Whitearil and red aril fruits were evaluated in an array of reagent-basedassays to determine nutritional and nutraceutical properties. Resultsand discussion. White arils and red arils showed similarphysicochemical characteristics, with high content of vitamin C(79.7–82.6 mg·100 g–1 fresh weight) and dietary fiber (5.83–6.12%fw). The anthocyanin content of red arils (29.5 mg·100 g–1 fw, ascyanidin-3-glucoside equivalents) was similar to that of strawberry.Total phenolics (517 mg·100 g–1 fw, as gallic acid equivalents)and antioxidant activities (ABTS, 224 mg; DPPH, 223 mg, as vitaminC equivalents) of red arils were 1.3 times higher than those inwhite arils. The methanolic extract of red arils showed a higherα-glucosidase inhibition (IC50 2.9 mg·mL–1) than acarbose (IC50 4.9 mg·mL–1).The methanolic extract [(50, 100 and 500) μg per tube] of red and whitearils showed positive-strong antimutagenic activities (inhibitionin the range 25–70%) in the assay (Salmonella typhimurium YG1024strain, 1-nitropyrene as mutagen, 200 ng per tube). We are reportingfor the first time remarkably high characteristics (i.e., antioxidant,inhibition of α-amylase and α-glucosidase and content of dietaryfiber) of P. dulce fruits, mainly of the red ones;properties which combined permit us to suggest that consumptionof these fruits could have beneficial health effects in people withdiabetes.