We present a case of plasmacytosis of the mucous membrane of the upper aerodigestive tract. This is a rare benign condition characterized by plasma cell infiltration of the mucosa, with only nine cases described previously (Ferreiro et al., 1994). The lesions, which have a cobblestone appearance, cause throat discomfort, dysphonia and mild dyspnoea. All the cases described previously failedto respond to antibiotics, systemic steroids, or to surgical resection. The present case has however responded favourably to intensive andprolonged treatment with beclamethasone oral spray and Corsodyl mouthwashes.