Microplastic pollution has become a global environmental challenge, with significant impacts on ecosystems and human health. Microbes have emerged as a promising tool in the combating against microplastic contamination. However, the complex relationship between microbes and microplastics presents both opportunities and challenges, leading to a nuanced understanding of their applications in degradation. This paper provides critical insights into the multifaceted roles of different microorganisms in microplastic degradation. It begins by highlighting the ‘good’ aspects, where several strains of microorganisms show the potential to break down microplastics through enzymatic activities and the formation of biofilms. Conversely, the ‘bad’ aspects of microbial involvement in microplastic degradation are examined. Microorganisms can facilitate the transport and bioaccumulation of microplastics in various ecosystems, potentially exacerbating their harmful effects. The ‘ugly’ side of microplastic degradation includes the production of harmful byproducts during microbial breakdown, raising concerns about secondary pollution and toxicity. The concept of plastisphere is discussed in this context, focusing on the phototrophs, photoheterotrophs and heterotrophs. Novel technologies involving microbial degradation of microplastics are also explained. The work emphasises the need for a comprehensive and balanced approach regarding the application of microorganisms in microplastic degradation and remediation.