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1 results

  • Antibodies from combinatorial libraries use functional receptor pleiotropism to regulate cell fates

  • Richard A. Lerner, Rajesh K. Grover, Hongkai Zhang, Jia Xie, Kyung Ho Han, Yingjie Peng, Kyungmoo Yea
  • Journal:
    Quarterly Reviews of Biophysics / Volume 48 / Issue 4 / November 2015
    Published online by Cambridge University Press:
    16 July 2015, pp. 389-394
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  • To date, most antibodies from combinatorial libraries have been selected purely on the basis of binding. However, new methods now allow selection on the basis of function in animal cells. These selected agonist antibodies have given new insights into the important problem of signal transduction. Remarkably, when some antibodies bind to a given receptor they induce a cell fate that is different than that induced by the natural agonist to the same receptor. The fact that receptors can be functionally pleiotropic may yield new insights into the important problem of signal transduction.