Let $M$ be a topological spherical space form, i.e., a smooth manifold whose universal cover is a homotopy sphere. We determine the number of path components of the space and moduli space of Riemannian metrics with positive scalar curvature on $M$ if the dimension of $M$ is at least 5 and $M$ is not simply-connected.

We extend the Atiyah, Patodi, and Singer index theorem for first-order differential operators from the context of manifolds with cylindrical ends to manifolds with periodic ends. This theorem provides a natural complement to Taubes’ Fredholm theory for general end-periodic operators. Our index theorem is expressed in terms of a new periodic eta-invariant that equals the Atiyah–Patodi–Singer eta-invariant in the cylindrical setting. We apply this periodic eta-invariant to the study of moduli spaces of Riemannian metrics of positive scalar curvature.

We decompose θ(M), the twisted index obstruction to a positive scalar curvature metric for closed oriented manifolds with spin universal cover, into a pairing of a twisted K-homology with a twisted K-theory class and prove that θ(M) does not vanish if M is a closed orientable enlargeable manifold with spin universal cover.