Response of weeds and sugarbeets (Beta vulgaris L. ‘Mono Hy D2′) to preplanting treatments of mixtures of cycloate (S-ethyl N-ethylthiocyclohexanecarbamate) and ethofumesate [(±)-2-ethoxy-2,3-dihydro-3,3-dimethyl-5-benzofuranyl methanesulfonate] was evaluated in five field studies. A mixture containing 1.7 kg/ha of each herbicide reduced the stand of common lambsquarters (Chenopodium album L.) 90%, green foxtail [Setaria viridis (L.) Beauv.] and yellow foxtail [Setaria lutescens (Weigel) Hubb.] 97 to 99%, kochia [Kochia scoparia (L.) Schrad.] 64 to 77%, and redroot pigweed (Amaranthus retroflexus L.) 82 to 99%. The response of weeds to preplanting applications of mixtures of cycloate and ethofumesate was independent of soil texture, whereas response of sugarbeets was dependent on soil texture. The herbicide mixtures significantly reduced the pre-thinning stand of sugarbeets and root and sucrose yields on two sandy loams, but not on a clay loam.