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pulmonary dysfunction

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Chapter 17 - Inflammation and Organ Damage during Cardiopulmonary Bypass
- By R Clive Landis, Sherif Assaad
Edited by Florian Falter, Albert C. Perrino, Jr, Robert A. Baker
Book:

Cardiopulmonary Bypass

Published online:

24 October 2022

Print publication:

10 November 2022, pp 166-174
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Summary

The transition from physiological circulation to cardiopulmonary bypass (CPB) represents a major change to the homeostasis of the body including alterations in the distribution of blood flow and oxygen delivery to organs, which may at least in part account for the organ dysfunction during CPB. Layered on top of disturbances in oxygen delivery is a systemic inflammatory response triggered by contact of leukocytes and other blood components with the artificial surfaces of the extracorporeal circuit. While most of these host responses are appropriate and desirable in the context of a localized injury or infection, they are not desirable systemically and contribute to the morbidity and mortality associated with cardiopulmonary bypass.