Three new species of coral reef boring sponges were found in remote coral reefs from Revillagigedo Island, an archipelago that is 386 km from the continent. Cliona medinae sp. nov. is a sponge with orange-yellow papillae characterized by short almost straight spirasters. Cliona tropicalis sp. nov., is a yellow papillate sponge with a spicule complement similar to the species included in the Cliona viridis complex. However, the new species differs from the rest of the species mainly in its external morphology and by differences in the size and shape of spicules. Thoosa purpurea sp. nov. is characterized by its purple colour, and the spicular complement formed by tylostyles, two amphiaster categories, bi- tri- and tetra-radiate oxyasters and smooth or microspined centrotylote oxeas. In addition, Cliothosa tylostrongylata sp. nov. is also described from coral reefs from the southern Mexican Pacific Ocean. This is a light red species, with tylostyles and tylostrongyles as megascleres and ramose and nodulose amphiasters as microscleres. The four species were found exclusively excavating skeletons of live or dead corals of the genus Pocillopora. This study increases the number of boring sponges known from the Mexican Pacific Ocean to 22 species and it is the first study on marine sponge fauna from the Revillagigedo archipelago.