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3 results

  • Genetic susceptibility for schizophrenia after adjustment by genetic susceptibility for smoking: implications in identification of risk genes and genetic correlation with related traits

  • Laila Al-Soufi, Javier Costas
  • Journal:
    Psychological Medicine / Volume 53 / Issue 14 / October 2023
    Published online by Cambridge University Press:
    06 March 2023, pp. 6806-6816
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  • Background

    Prevalence of smoking in schizophrenia (SCZ) is larger than in general population. Genetic studies provided some evidence of a causal effect of smoking on SCZ. We aim to characterize the genetic susceptibility to SCZ affected by genetic susceptibility to smoking.

    Methods

    Multi-trait-based conditional and joint analysis was applied to the largest European SCZ genome-wide association studies (GWAS) to remove genetic effects on SCZ driven by smoking, estimated by generalized summary data-based Mendelian randomization. Enrichment analysis was performed to compare original v. conditional GWAS. Change in genetic correlation between SCZ and relevant traits after conditioning was assessed. Colocalization analysis was performed to identify specific loci confirming general findings.

    Results

    Conditional analysis identified 19 new risk loci for SCZ and 42 lost loci whose association with SCZ may be partially driven by smoking. These results were strengthened by colocalization analysis. Enrichment analysis indicated a higher association of differentially expressed genes at prenatal brain stages after conditioning. Genetic correlation of SCZ with substance use and dependence, attention deficit-hyperactivity disorder, and several externalizing traits significantly changed after conditioning. Colocalization of association signal between SCZ and these traits was identified for some of the lost loci, such as CHRNA2, CUL3, and PCDH7.

    Conclusions

    Our approach led to identification of potential new SCZ loci, loci partially associated to SCZ through smoking, and a shared genetic susceptibility between SCZ and smoking behavior related to externalizing phenotypes. Application of this approach to other psychiatric disorders and substances may lead to a better understanding of the role of substances on mental health.

  • Parenting style, coping efficacy, and risk-taking behavior in Chinese young adults

  • Chengting Ju, Rina Wu, Baoshan Zhang, Xuqun You, Yun Luo
  • Journal:
    Journal of Pacific Rim Psychology / Volume 14 / 2020
    Published online by Cambridge University Press:
    13 January 2020, e3
    Print publication:
    2020
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  • The goal of this study was to examine the relationship between three parenting styles (warmth, rejection, and overprotection), coping efficacy and risk-taking behavior in Chinese young adults. A total of 719 subjects completed three instruments: the Egna Minneu av Bardndosnauppforstran, the Coping Efficacy Questionnaire and the Adolescent Risk-Taking Questionnaire. Structural equation modeling results showed that maternal warmth (negatively) and rejection (positively), but not overprotection, correlated with risk-taking behavior via coping efficacy, whereas paternal rejection and overprotection (positively), but not warmth, correlated with risk-taking behavior via coping efficacy. These results suggest that parenting styles indirectly associate with risk-taking behavior through coping efficacy in young adults.

  • The likelihood of divorce and the riskiness of financial decisions

  • Oded Stark, Krzysztof Szczygielski
  • Journal:
    Journal of Demographic Economics / Volume 85 / Issue 3 / September 2019
    Published online by Cambridge University Press:
    22 August 2019, pp. 209-229
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  • We link causally the riskiness of men's management of their finances with the probability of their experiencing a divorce. Our point of departure is that when comparing single men to married men, the former manage their finances in a more aggressive (that is, riskier) manner. Assuming that single men believe that low relative wealth has a negative effect on their standing in the marriage market and that they care about their standing in that market more than married men do, we find that a stronger distaste for low relative wealth translates into reduced relative risk aversion and, consequently, into riskier financial behavior. With this relationship in place we show how this difference varies depending on the “background” likelihood of divorce and, hence, on the likelihood of re-entry into the marriage market: married men in environments that are more prone to divorce exhibit risk-taking behavior that is more similar to that of single men than married men in environments that are little prone to divorce. We offer a theoretical contribution that helps inform and interpret empirical observations and regularities and can serve as a guide for follow-up empirical work, having established and identified the direction of causality.