This paper analyses the occupation sequence documented in the Roman house of La Fortuna (Cartagena, Spain). We use a contextual approach to study all the material culture documented in the domus. We start with a complete re-documentation of the stratigraphic record, in order to match the finds to their provenance. As a basis for this documentation, we discuss the abandonment typologies and the formation processes documented in the house. Using this framework we make a detailed examination of the artefact assemblages documented and we apply a quantitative study of the production, redistribution and consumption patterns during the different occupation phases. The ultimate objective of this paper is to provide a social and economic reading of the household activities carried out by the successive inhabitants in their own historical context.