Despite growing interest in Thomas Aquinas' biblical exegesis in general, and in his reading of Romans in particular, little attention has been given to the way Thomas actually uses scripture to do theology in his most enduring and influential work: the Summa theologiae. This article makes a preliminary attempt to remedy this neglect by exploring the role played by Romans 1:19-20 in the Summa. Given the deep connection of both Romans 1 and Aquinas to the perennial debates about natural theology, we might expect Thomas’ engagement with those verses to be concerned chiefly and resolutely with the questions animating these debates. But this is not at all the case. Far from being limited to arguments for philosophical knowledge of God, the Summa's more than twenty citations of Romans 1, I argue, re-present the whole drama of Christianity in microcosm. Even according to the letter, Paul's words have many senses for Thomas. The goal of this article is to draw out these many senses and demonstrate the creative interplay of scripture and theology in Thomas’ Summa.