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2 results

  • Asymptotic results for a problem of DNA breakage

  • Richard Cowan, David Culpin, David Gates
  • Journal:
    Journal of Applied Probability / Volume 27 / Issue 2 / June 1990
    Published online by Cambridge University Press:
    14 July 2016, pp. 433-439
    Print publication:
    June 1990

  • Double-stranded DNA molecules can be damaged by enzymic action or radiation, in a manner which creates randomly-located single-stranded breaks (nicks). The accumulation of these leads eventually to the double-stranded breakage of the molecule, because two opposite-strand nicks within a critical distance of each other establish conditions for breakage. We study the random variable N, defined as the number of nicks needed for double-stranded breakage to occur. We develop an asymptotic theory which is needed for practical computations.