Aiming at alleviating the adverse influence of coupling unmodeled dynamics, actuator faults and external disturbances in the attitude tracking control system of tilt tri-rotor unmanned aerial vehicle (UAVs), a neural network (NN)-based robust adaptive super-twisting sliding mode fault-tolerant control scheme is designed in this paper. Firstly, in order to suppress the unmodeled dynamics coupled with the system states, a dynamic auxiliary signal, exponentially input-to-state practically stability and some special mathematical tools are used. Secondly, benefiting from adaptive control and super-twisting sliding mode control (STSMC), the influence of the unexpected chattering phenomenon of sliding mode control (SMC) and the unknown system parameters can be handled well. Moreover, NNs are employed to estimate and compensate some unknown nonlinear terms decomposed from the system model. Based on a decomposed quadratic Lyapunov function, both the bounded convergence of all signals of the closed-loop system and the stability of the system are proved. Numerical simulations are conducted to demonstrate the effectiveness of the proposed control method for the tilt tri-rotor UAVs.