The years surrounding the origins of the term “Manifest Destiny” were a transitional period in the history of industrialization. Historians have done much to analyze the impact of major technological shifts on business structure and management, and to connect eastern markets and westward expansion. They have paid less attention, however, to the relationship among continental geopolitics, industrial development, and frontier warfare. This article uses War Department papers, congressional reports, and manufacturers’ records to examine how the arms industry developed in response to military conflict on the frontier. As public and private manufacturers altered production methods, product features, and their relationships to one another, they contributed to the industrial developments of the mid-nineteenth century.