Let n=2,3,4,5 and let X be a smooth complex projective hypersurface of . In this paper we find an effective lower bound for the degree of X, such that every holomorphic entire curve in X must satisfy an algebraic differential equation of order k=n=dim X, and also similar bounds for order k>n. Moreover, for every integer n≥2, we show that there are no such algebraic differential equations of order k<n for a smooth hypersurface in .