The evolution of the progressive loss of semantic knowledge of a
patient, VZ, with lesions mainly affecting the infero-medial temporal
lobes, was followed for two years. At the beginning of the study VZ's
performance was mainly characterized by a category-specific deficit for
living things and a modality-specific deficit for perceptual attribute
knowledge. As time went on, VZ's disorder affected all categories by
changing the relationship between category and attribute knowledge. Data
show that dissociations may change in the course of progressive cognitive
breakdown, depending on both degeneration stage and task demands.
VZ's performance is discussed in the light of the most influential
theoretical accounts. Methodological suggestions regarding longitudinal
studies of degenerative patients are also put forward. (JINS,
2006, 12, 275–284.)