In this article I present new calculations for the evolution of prices and standards of living in Seville from 1521 to 1603. Using new data on prices and new research on changes in nutrition and consumption, I improve the consumer price index. Two major improvements can be highlighted: the inclusion of rented housing prices and the use of three baskets of goods, according to the transformations identified in the consumption patterns. As a result of these improvements, the new data show that prices increase more (336%) than previously estimated by Hamilton (155%) and when using the Allen method (234%). Consequently, real wages decrease more with the new index (32%).