The present study assessed alertness, memory, and performance
following three schedules of ∼8 hr of sleep loss (slow,
intermediate, and rapid accumulation) in comparison to an 8-hr
time in bed (TIB) sleep schedule. Twelve healthy individuals
aged 21–35 completed each of four conditions according
to a Latin Square design: no sleep loss (8-hr TIB for 4 nights;
2300–0700), slow (6-hr TIB for 4 nights; 0100–0700),
intermediate (4-hr TIB for 2 nights; 0300–0700), and rapid
(0-hr TIB for 1 night) sleep loss. On each day, participants
completed a multiple sleep latency test (MSLT), a probed-recall
memory task, a psychomotor vigilance task, a divided attention
task, and the Profile of Mood States. “Rapid” sleep
loss produced significantly more impairment on tests of alertness,
memory, and performance compared to the “slow”
accumulation of a comparable amount of sleep loss. The impairing
effects of sleep loss vary as a function of rate, suggesting
the presence of a compensatory adaptive mechanism operating
in conjunction with the accumulation of a sleep debt.