Due to the diversity of antibody (Ab)-based biochips chemistries available and the little knowledge about biochips resistance to space constraints, immobilization of Abs on the surface of the biochips dedicated to Solar System exploration is challenging. In the present paper, we have developed ten different biochip models including covalent or affinity immobilization with full-length Abs or Ab fragments. Ab immobilizations were carried out in oriented/non-oriented manner using commercial activated surfaces with N-hydroxysuccinic ester (NHS-surfaces) or homemade surfaces using three generations of dendrimers (dendrigraft of poly L-lysine (DGL) surfaces). The performances of the Ab -based surfaces were cross-compared on the following criteria: (i) analytical performances (expressed by both the surface density of immobilized Abs and the amount of antigens initially captured by the surface) and (ii) resistance of surfaces to preparation procedure (freeze-drying, storage) or spatial constraints (irradiation and temperature shifts) encountered during a space mission. The latter results have been expressed as percentage of surface binding capacity losses (or percentage of remaining active Abs). The highest amount of captured antigen was achieved with Ab surfaces having full-length Abs and DGL-surfaces that have much higher surface densities than commercial NHS-surface. After freeze-drying process, thermal shift and storage sample exposition, we found that more than 80% of surface binding sites remained active in this case. In addition, the resistance of Ab surfaces to irradiation with particles such as electron, carbon ions or protons depends not only on the chemistries (covalent/affinity linkages) and strategies (oriented/non-oriented) used to construct the biochip, but also on the type, energy and fluence of incident particles. Our results clearly indicate that full-length Ab immobilization on NHS-surfaces and DGL-surfaces should be preferred for potential use in instruments for planetary exploration.

Research on new techniques of multi-chamber mufflers equipped with a side inlet and internal nonperforated intruding tubes has been discussed in recent literature; however, the research work of multichamber mufflers in conjunction with side inlet and open-ended perforated intruding tubes which may efficiently increase the acoustical performance has been neglected. Therefore, the main purpose of this paper is to optimize the best design shape of multi-chamber side mufflers with open-ended perforated intruding tubes within a limited space.

In this paper, the four-pole system matrix in evaluating the acoustic performance is also deduced in conjunction with a simulated algorithm (SA). Results reveal that the maximum sound transmission loss (STL) is precisely located at the desired target tone. In addition, the acoustical performance of mufflers conjugated with perforated intruding tubes is superior to those equipped with non-perforated tubes. Additionally, the noise reduction ability for a three-chamber side muffler with a non-perforated intruding tube and a two-chamber side muffler with perforated intruding tubes are equivalent. Moreover, mufflers with more chambers will increase the acoustic performance for both pure tone and broadband noise.

Research on new techniques of side-inlet/outlet mufflers equipped with internal non-perforated intruding tubes has been discussed in recent literature; however, the research work of multi-chamber sideinlet/outlet mufflers in conjunction with cross-flow tubes and open-ended perforated intruding tubes which may efficiently increase the acoustical performance is rare. Therefore, the main purpose of this paper is not only to analyze the sound transmission loss (STL) of three kinds of side-inlet/outlet mufflers (a three-chamber muffler with cross-flow tubes, a five-chamber muffler with cross-flow tubes and a nonperforated tube, and a five-chamber muffler with cross-flow tubes and a perforated tube) but also to optimize their best design shape within a limited space.

In this paper, both the generalized decoupling technique and plane wave theory in solving the coupled acoustical problem are used. A four-pole system matrix in evaluating the acoustic performance is also deduced in conjunction with a simulated algorithm (SA). A numerical case in finding the optimal STL of mufflers, which is constrained within a basement with a side-inlet/outlet, at targeted tones has been introduced. Before the optimization is carried out, an accuracy check of the mathematical model is performed. Results reveal that the maximal STL is precisely located at the desired target tone. Moreover, it has been seen that mufflers with more chambers will increase the acoustic performance for both pure tone and broadband noise. Additionally, the acoustical performance of mufflers conjugated with perforated intruding tubes is superior to those equipped with non-perforated tubes.

Consequently, the approach used for seeking the optimal design of the STL proposed in this study is indeed easy and quite effective.

In order to reduce the venting noise within a confined room, the development of a high performance muffler within certain space constraints is imperative. Therefore, the main purpose of this paper is to develop an optimally shaped one-chamber cross-flow perforated muffler that will dramatically increase the acoustical performance within a limited space.

On the basis of plane wave theory, a four-pole system matrix for evaluating acoustical performance is derived by using a decoupled numerical method. Moreover, in order to search for a global optimum, a genetic algorithm (GA) with tournament selection in elitism and uniform crossover/mutation (analogous to a genes' evolutionary process) has been used for the mufflers' optimization. To assure the GAs' correctness, the STLs' maximization of one-chamber cross-flow perforated mufflers with respect to three targeted frequencies (200, 400, and 800Hz) is exemplified. Furthermore, a numerical case for dealing with an octave band noise emitted from an air compressor using one-chamber cross-flow mufflers has been introduced and fully discussed. To achieve a better optimization with the GA, various GA parameter sets were used. Before the GA operation is carried out, the mathematical models of cross-flow perforated mufflers are verified by comparing the numerical result and experimental data with those obtained by Sullivan and Wu respectively.

Consequently, the results reveal that the acoustical performance for a cross-flow perforated muffler is excellent. Moreover, they reveal that the optimization approach proposed in this study is easy, economical, and quite effective.