Prostate cancer is the second most common malignancy in American men. High-dose-rate brachytherapy is a popular treatment technique in which a large, localized radiation dose is used to kill cancer. Utilization of curvilinear catheter implantation inside the prostate gland to provide access channels to host the radiation source has shown superiority in terms of improved dosimetric constraints compared to straight needles. To this aim, we have introduced an active needle to curve inside the prostate conformal to the patient’s specific anatomical relationship for improved dose distribution to the prostate and reduced toxicity to the organs at risk. This work presents closed-loop control of our tendon-driven active needle in water medium and air using the position feedback of the tip obtained in real time from an ultrasound (US) or an electromagnetic (EM) tracking sensor, respectively. The active needle consists of a compliant flexure section to realize bending in two directions via actuation of two internal tendons. Tracking errors using US and EM trackers are estimated and compared. Results show that the bending angle of the active needle could be controlled using position feedback of the US or the EM tracking system with a bending angle error of less than 1.00 degree when delay is disregarded. It is concluded that the actuation system and controller, presented in this work, are able to realize a desired bending angle at the active needle tip with reasonable accuracy paving the path for tip tracking and manipulation control evaluations in a prostate brachytherapy.

In this article, we review the main results achieved by the research activities carried out at PRISMA Lab of the University of Naples Federico II where, for 35 years, an interdisciplinary team of experts developed robots that are ultimately useful to humans. We summarize the key contributions made in the last decade in the six research areas of dynamic manipulation and locomotion, aerial robotics, human-robot interaction, artificial intelligence and cognitive robotics, industrial robotics, and medical robotics. After a brief overview of each research field, the most significant methodologies and results are reported and discussed, highlighting their cross-disciplinary and translational aspects. Finally, the potential future research directions identified are discussed.

Flexible endoscopy is the gold standard modality for diagnosis and therapeutic intervention of various colorectal conditions. A high bar is currently set for any new technology to replace the current modern colonoscope, but limitations do exist. For a robotic system to gain acceptance, ideally a clear advantage over the established standard needs to be demonstrated. The application of robotic technology inspired by locomotion observed in animals has been demonstrated in many fields including colonoscopy. A myriad of novel concepts has been proposed, which can overcome the anatomical and technical challenges.

This review discusses novel and innovative examples of bioinspired robotic locomotion in the colon with a detailed comparison of studies alongside separating the discussion by animal sections of insect, marine and reptile locomotion. We also discuss the current advantages and challenges a bioinspired robot will bring to the colon.

Bioinspired robotics in the colon is an exciting field of research with the potential to improve upon current existing high standards of practice in colonoscopy. By addressing areas that the conventional colonoscope is weaker in, studies are demonstrating improvement upon current limitations of standard practice and providing an insight into new methods of engineering and fabrication. Focus on the technological, mechanical and regulatory barriers is key to achieve acceptance into standard practice and will allow the aspiration of a safe, low discomfort, low cost and potentially fully autonomous robotic colonoscope to be not too distant in the future of colonoscopy.

Instrument delivery is critical part in vascular intervention surgery. Due to the soft-body structure of instruments, the relationship between manipulation commands and instrument motion is non-linear, making instrument delivery challenging and time-consuming. Reinforcement learning has the potential to learn manipulation skills and automate instrument delivery with enhanced success rates and reduced workload of physicians. However, due to the sample inefficiency when using high-dimensional images, existing reinforcement learning algorithms are limited on realistic vascular robotic systems. To alleviate this problem, this paper proposes discrete soft actor-critic with auto-encoder (DSAC-AE) that augments SAC-discrete with an auxiliary reconstruction task. The algorithm is applied with distributed sample collection and parameter update in a robot-assisted preclinical environment. Experimental results indicate that guidewire delivery can be automatically implemented after 50k sampling steps in less than 15 h, demonstrating the proposed algorithm has the great potential to learn manipulation skill for vascular robotic systems.

Because of the increasing use of laparoscopic surgeries, robotic technologies have been developed to overcome the challenges these surgeries impose on surgeons. This paper presents an overview of the current state of surgical robots used in laparoscopic surgeries. Four main categories were discussed: handheld laparoscopic devices, laparoscope positioning robots, master–slave teleoperated systems with dedicated consoles, and robotic training systems. A generalized control block diagram is developed to demonstrate the general control scheme for each category of surgical robots. In order to review these robotic technologies, related published works were investigated and discussed. Detailed discussions and comparison tables are presented to compare their effectiveness in laparoscopic surgeries. Each of these technologies has proved to be beneficial in laparoscopic surgeries.

This work addresses the gravity balancing of a 2R1T (2 rotations – 1 translation) mechanism with remote center of motion. A previously developed balancing solution is modified and applied to a prototype, and test results are presented. The mechanism is an endoscope holder for minimally invasive transnasal pituitary gland surgery. In this surgery, the endoscope is inserted through a nostril of the patient through a natural path to the pituitary gland. During the surgery, it is vital for the manipulator to be statically balanced so that in case of a motor failure, the patient is protected against any harmful motion of the endoscope. Additionally, static balancing takes the gravitational load from the actuators and hence facilitates the control of the mechanism. The mechanism is a 2URRR-URR type parallel manipulator with three legs. The payload mass is distributed to the legs on the sides. By using counter-masses for two links of each leg, the center of mass of each leg is lumped on the proximal link which simplifies the problem of balancing of a two degree-of-freedom inverted pendulum. The two proximal links with the lumped mass are statically balanced via springs. Dynamic simulations indicate that when the mechanism is statically balanced, generated actuator torques are reduced by 93.5%. Finally, the balancing solution is implemented on the prototype of the manipulator. The tests indicate that the manipulator is statically balanced within its task space when the actuators are disconnected. When the actuators are connected, the torque requirements decrease by about 37.8% with balancing.

To overcome the physical limitations of mechanical bone cutting in minimally invasive surgery, we are developing a miniature parallel robot that enables positioning of a pulsed laser with an accuracy below 0.25 mm and minimizes the required manipulation space above the target tissue. This paper presents the design, control, device characteristics, functional testing, and performance evaluation of the robot. The performance of the robot was evaluated within the scope of a path-following experiment. The required accuracy for continuous cuts was achieved and reached 0.176 mm on the test bench.

This paper aims at estimating the tremor torque using extended Kalman filter (EKF) applied to a two-link 3-DOF robot with nonlinear dynamics modelled using Lie-group and Lie-algebra theory. Later, it is generalised to d number of links with (d + 1) -DOF. The configuration of each link at any time is described by its rotation relative to the preceding link. Using this formulation, an elegant formula for the kinetic energy of the (d + 1) -DOF system is obtained as a quadratic form in the angular velocities with coefficients being highly nonlinear trigonometric functions of the angles. Properties of the Lie algebra generators and the Lie adjoint map are used to arrive at this expression. Further, the gravitational potential energy and the torque potential energy are expressed as nonlinear trigonometrical functions of the angles using properties of the SO(3) group. The input torque comprises a nonrandom intentional torque component and a highly nonlinear tremor torque component. The tremor torque is modelled as a stochastic differential equation (sde) satisfying Ornstein–Uhlenbeck (OU) process with diffusion and damping coefficients. Further, the tremor is treated as the disturbance. The Euler–Lagrange equations for the angles are derived. These form a system of sdes, and the EKF is used to get a more accurate disturbance estimate than that provided by the usual disturbance observer. The EKF is based on noisy angle measurements and yields as a bonus the angle and angular velocity estimates on a real-time basis. The parameters in the OU process model of the tremor torque, and parameters of the Fourier components of the intentional torque have also been estimated.

A continuum manipulator, such as a multisection trunk/tentacle robot, performs manipulation tasks by continuously deforming into different concave shapes. While such a robot is promising for manipulating a wide range of objects in less-structured and cluttered environments, it poses a greater challenge to collision detection than conventional, articulated manipulators. Existing collision detection algorithms are built upon intersection checking between convex primitives, such as between two convex polygons or polyhedra, with the assumption that both the manipulator and the objects in the environment are modeled in terms of those primitives, for example, as polygonal meshes. However, to approximate a continuum manipulator with a polygonal mesh requires a fine mesh because of its concavity, and each time the manipulator changes its configuration by deforming its shape, the mesh has to be updated for the new configuration. This makes mesh-based collision detection involving such a robot much more computationally expensive than that involving an articulated manipulator with rigid links.

Hence, we introduce an efficient algorithm for Collision Detection between a Continuum Manipulator (CD-CoM) and its environment based on analytical intersection checking with nonconvex primitives. Our algorithm applies to the exact model of any continuum manipulator consisting of multiple uniform-curvature sections of toroidal and (sometimes) cylindrical shapes as well as more general continuum manipulators whose sections can be approximated by toroidal and cylindrical primitives. Our test results show that using this algorithm is both more accurate and efficient in time and space to detect collisions than approximating a continuum manipulator as a polygonal mesh. Moreover, the CD-CoM algorithm also provides the minimum distance information between the continuum manipulator and objects when there is no collision. Such an efficient algorithm is essential for path/trajectory planning of continuum manipulators in real-time.

Many recent developments of surgical robots focus on less invasive paradigms, such as laparoscopic SPA (Single Port Access) surgery, NOTES (Natural Orifice Translumenal Endoscopic Surgery), laryngoscopic MIS (Minimally Invasive Surgery), etc. A configuration similarity shared by these surgical robots is that two or more manipulators are inserted through one access port (a laparoscope, an endoscope, or a laryngoscope) for surgical interventions. However, upon designing such a surgical robot, the structure of the inserted manipulators has not been thoroughly explored based on evaluation of their performances. This paper presents a comparison for kinematic performances among three different continuum manipulators. They all could be applied in the aforementioned surgical robots. The structural parameters of these continuum manipulators are firstly optimized to assure a more fair and consistent comparison. This study is conducted in a dimensionless manner and provides scalable results for a wide spectrum of continuum manipulator designs as long as their segments have a constant curvature. The results could serve as a design reference for future developments of surgical robots which use one access port and continuum mechanisms.

The tip of a flexible needle with a bevel tip approximately follows a planar arc when it is inserted into soft tissue only with the force applied to the needle along the needle axis. The direction of the arc can be controlled by the rotation input around the needle axis. This flexible and steerable needle has been shown to have a considerable potential in clinical applications due to its maneuverability and steerability. Beyond the needle insertion to a single destination, this paper concerns obtaining needle trajectories that reach multiple targets. Specifically, we propose an algorithm for the insertion of a flexible needle to travel from a single insertion point (i.e. port) to multiple targets. The insertion is motivated by the observation that multiple targets can be reached by the flexible needle through a combination of insertion, partial retraction, turning, and reinsertion of the flexible needle. In this paper we develop an insertion algorithm that minimizes tissue damage during the needle insertion to multiple targets. To this end, a cost function which computes the length of needle trajectory that can be thought of as the tissue damage is defined, and is minimized. Through the minimization, we find the optimal insertion parameters such as the port location, the insertion direction at the port, the targeting order, the turning angles, and the lengths of forward insertions and retractions. To reduce the computation time, we perform workspace analysis for this approach to filter out the no-solution cases. We present numerical examples of the simulated needle insertion for multiple targets with and without obstacles and show the benefit of the proposed method in terms of the tissue damage and the number of skin punctures. Extensions of the proposed approach to more complex cases such as more than three target points and maneuvering around spherical obstacles are also discussed.

Series elastic actuators have beneficial properties for some robot applications. Several recent implementations contain alternative placements of the compliant element to improve instrumentation design. We use a class 1 versus class 2 lever model and energy-port methods to demonstrate in this paper that these alternative placements should still be classified as series elastic actuators. We also note that the compliance of proximal series elastic actuators is reflected by an augmented gear ratio dependent on the nominal gear ratio, which is significant for small gear ratios and approaches unity for large gear ratios. This reflected compliance is shown to differ depending on the sign of the gear ratio. We demonstrate that although the reflected compliance is only marginally influenced by the magnitude of the gear ratio, there are several notable differences, particularly for small gear ratios.

Surgical and search/rescue robots often work in environments with very strict spatial constraints. The tendon-sheath mechanism is a promising candidate for driving such systems, allowing power sources and actuation motors placed outside to transmit force and energy to the robot at the distal end through the constrained environment. Having both compactness and high force capability makes it very attractive for manipulation devices. On the other hand, the friction attenuation of tendon tension is nonlinear and configuration-dependent due to tendon/sheath interactions throughout the transmission path. This is a major obstacle for the tendon-sheath mechanism to be widely adopted. Here, we focus on the friction analysis for flexible and time-varying tendon-sheath configurations: the most challenging but yet commonly encountered case for real-world applications. Existing results on fixed-path configurations are reviewed, revisited, and extended to flexible and time-varying cases. The effect of tendon length to friction attenuation is modeled. While focusing on tension transmission, tendon elongation is also discussed with the length effect applied. In the end, two-dimensional results are extended to three-dimensional tendon-sheath configurations. All propositions and theorems are validated on a dedicated experimental platform.

This paper deals with processes of optimisation for the design of a four degree-of-freedom robot dedicated to remote ultrasound tele-echography. This robot is designed to track the medical gestures of a remote expert moving an ultrasound probe. The goal is to optimise the kinematic structure by fixing the geometric parameters; these have a significant role in robot configuration singularities, with respect to current medical gestures and mechanism compactness. After choosing a dedicated kinematic structure, several optimisations are presented. Then an optimal choice of geometrical parameters of a global function in relation with kinematic performance indices and compactness is proposed. This robot is soon to be used in the experimental medical phase of the Prosit project.

Tendon sheath actuation is found in many applications, particularly in robotic hands and surgical robots. Due to the friction between the tendon and sheath, many undesirable characteristic such as backlash, hysteresis and non-linearity are present. It is desirable to know the end-effector force and elongation of the tendon to control the system effectively, but it is not always feasible to fix sensors at the end effector. A method to estimate the end-effector parameters using only a force and position sensor at the proximal site is given. An analytical study is presented and experiments are reported to support the result, showing a maximum full-scale error of approximately 7%. This result is achieved if the shape of the sheath remains the same and buckling is negligible. The results presented in this study could contribute towards haptic development in robotics surgery.

When computer vision technique is used in robotics, robotic hand–eye calibration is a very important research task. Many algorithms have been proposed for hand–eye calibration. Based on these algorithms, we introduce a new hand–eye calibration algorithm in this paper, which employs the screw motion theory to establish a hand–eye matrix equation by using quaternion and gets a simultaneous result for rotation and translation by solving linear equations. The algorithm proposed in this paper has high accuracy and stable computational efficiency and can be understood easily. Both simulations and real experiments show the superiority of our algorithm over the comparative algorithms.