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1 results

  • Glaucoma may be a non-memory manifestation of Alzheimer's disease in older people

  • Shih-Wei Lai, Cheng-Li Lin, Kuan-Fu Liao
  • Journal:
    International Psychogeriatrics / Volume 29 / Issue 9 / September 2017
    Published online by Cambridge University Press:
    29 May 2017, pp. 1535-1541
  • Background:

    The purpose of this paper was to examine whether glaucoma could be a non-memory manifestation of Alzheimer's disease in older people.

    Methods:

    We conducted a population-based, retrospective, case-control study to analyze the database of the Taiwan National Health Insurance Program. There were 1,351 subjects ≥65 years old with newly diagnosed Alzheimer's disease as the cases, and 5,329 subjects without any type of dementias as the controls during 2000–2011. The odds ratio (OR) and 95% confidence interval (CI) for the risk of Alzheimer's disease associated with glaucoma was estimated by the multivariable unconditional logistic regression model.

    Results:

    After controlling for confounders, the multivariable logistic regression model demonstrated that the adjusted OR of Alzheimer's disease was 1.50 in subjects with glaucoma (95% CI 1.19, 1.89), compared to subjects without glaucoma.

    Conclusions:

    Older people with glaucoma are associated with 1.5-fold increased odds of Alzheimer's disease in Taiwan. Glaucoma may be a non-memory manifestation of Alzheimer's disease in older people. Further research is needed to confirm this issue.