Tang expansion in the early seventh century brought about a series of changes to the eastern Tianshan region, including the incorporation of the region into the imperial postal relay and defence system. Important structures, including cities for the soldiers and other immigrants from Tang territory, along with fortresses and relay posts, were established along the major routes in the region, especially on the northern slopes of the Tianshan range. However, the era after the decline of the Tang is not as well known, due to a lack of contemporary sources. This article, based on a comprehensive analysis of documentary and unearthed materials, discusses a previously unacknowledged process of urbanisation in the region during the Uighur era. Uighur immigrants, originally nomads on the Mongolian steppe, occupied not only the cities, but also the garrisons and other infrastructure established by the Tang. As a result, urban settlements were established at sites that had previously served military purposes. Clusters of new cities emerged in the region, especially on the northern slopes of the Tianshan, which had long been part of the nomadic cultural zone. The sedentary and mercantile culture of the Uighurs played an important role in this process, serving as an impetus for economic prosperity along the eastern section of the Silk Road between the Tang and Mongol–Yuan eras.