A new method for predicting manoeuvre loads on a large transport aircraft with a swept-back wing and a load alleviation system based on control surface deflections is developed. For this purpose, three-dimensional Reynolds-averaged Navier–Stokes (RANS) simulations of the rigid wing–fuselage configuration are performed while the aerodynamics of the tailplane are estimated by means of handbook methods. For a closer analysis, different quasi-steady pitching manoeuvres are chosen based on the CS-25 regulations. One of these manoeuvres is also simulated with active load alleviation, leading to a reduction in the wing-root bending moment by more than 40%. Besides demonstrating the potential of the considered load alleviation system, it is shown which manoeuvres are especially critical in this context and which secondary effects come along with load alleviation.