Meteorological extremes such as heatwaves and water limitations during the ripening season could negatively impact vine ecophysiology and berry metabolism resulting in lower yield per vine. This project aimed to compare two different soil managements during two growing-production seasons (2021 and 2022) with respect to control without any treatment (control). The two managements were: Zeowine (30 t/ha; a soil conditioner made with clinoptilolite and compost proceeding of industrial wine-waste) and compost (20 t/ha). The trial was organized at Col d'Orcia Estate (Montalcino, Tuscan wine region, Italy). The purpose was twofold: (1) to evaluate the effects of Zeowine treatments on leaf gas exchanges, midday stem water potential, chlorophyll fluorescence and leaf temperature (ecophysiology); and (2) to determine any repercussions on the quality of the grapes (technological and phenolics analyses). The parameters plant yield, yeast assimilable nitrogen, fractionation of anthocyanins (cyanidin, delphinidin, malvidin, peonidin and petunidin), caffeic acid, coumaric acid, gallic acid, ferulic acid, kaempferol and quercetin were also analysed. Zeowine showed higher photosynthesis, less negative midday water potential and lower leaf temperature. Essentially, no significant difference was found between the compost and the control. Furthermore, Zeowine grapevines showed higher anthocyanin accumulation and less quercetin content. In general, compost applied together with zeolite could alleviate the adverse effects of water stress and improve plant growth, yield and quality. The control management strategy proved to be the least beneficial for the well-being of the plant and the final quality of the product, confirming the need for amendments in critical years.