Greenhouse studies were conducted to evaluate potential interactions among glyphosate mixtures with five acetolactate synthase (ALS)-inhibiting herbicides (chlorimuron, imazamox, imazaquin, MON 12,000, or pyrithiobac) for the control of purple nutsedge and sicklepod at two growth stages. Herbicides were tested alone at 0.5X and 1X rates (1X being suggested use rate for these herbicides) and in combination with glyphosate at 560 (0.5X) and 1,120 (1X) g ai/ha on 3-wk-old plants and at 1,120 g/ha on 6-wk-old plants. Glyphosate alone at 1,120 g/ha gave complete control of purple nutsedge and at least 78% control of sicklepod regardless of growth stage. In 3-wk-old purple nutsedge plants, three of the 20 herbicide combinations were antagonistic and 17 combinations were additive, whereas all five combinations were additive in 6-wk-old plants. In sicklepod, eight combinations were antagonistic and 12 combinations were additive in 3-wk-old plants, and all five combinations were antagonistic in 6-wk-old plants. In 3-wk-old plants, the glyphosate (0.5X) plus imazaquin (0.5X) combination resulted in highest antagonism in purple nutsedge control (79%), and the combination of glyphosate (0.5X) plus imazamox (0.5X) resulted in highest antagonism in sicklepod control (54%). These results indicate that mixing chlorimuron, imazamox, imazaquin, MON 12,000, or pyrithiobac with glyphosate does not increase glyphosate efficacy on purple nutsedge or sicklepod.