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The expansion of COVID-19 diagnostic testing across the USA was – and continues to be – essential to slowing and preventing the spread of COVID-19. This chapter summarizes the efforts of the Rapid Acceleration of Diagnostics (RADx®) Tech team to (1) provide science-based outputs to assess and guide specific mitigation and testing strategies, (2) demonstrate how COVID-19 prevention and containment efforts can most effectively be combined with the latest testing strategies to minimize the spread of the virus in a semi-contained population, and (3) deliver personal recommendations based on how likely an individual is to get COVID-19 and spread it to other people. Details are provided on a data-driven model to mitigate disease spread that is based on a simple counting exercise known in different disciplines as a control volume approach or queueing theory. The effects of social distancing, mask wearing, vaccination, and contact tracing on disease spread and testing requirements are explored. The US government public policy effect on testing is also discussed.
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