Four experiments (three in Macedonia, Greece and one in Holtville, CA) were conducted in 1988 and 1989 to evaluate foliar applications of picloram, glyphosate alone and with adjuvant, and triclopyr for the control of established silverleaf nightshade. Silverleaf nightshade control was determined by comparing stem population at the time of herbicide application to stem population 6 to 11 mo after application. Picloram, averaged over rate and location, controlled silverleaf nightshade consistently, restricting regrowth to less than 5%. Silverleaf nightshade control with glyphosate alone or with adjuvant varied with location, regrowth ranged from 0 to 69%. Regrowth of silverleaf nightshade treated with triclopyr approached that of the untreated control.