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1 results

  • The Hair Follicle Bulge: A Niche for Adult Stem Cells

  • Hilda Amalia Pasolli
  • Journal:
    Microscopy and Microanalysis / Volume 17 / Issue 4 / August 2011
    Published online by Cambridge University Press:
    05 July 2011, pp. 513-519
    Print publication:
    August 2011

  • Adult stem cells (SCs) are essential for tissue homeostasis and wound repair. They have the ability to both self-renew and differentiate into multiple cell types. They often reside in specialized microenvironments or niches that preserve their proliferative and tissue regenerative capacity. The murine hair follicle (HF) has a specialized and permanent compartment—the bulge, which safely lodges SCs and provides the necessary molecular cues to regulate their function. The HF undergoes cyclic periods of destruction, regeneration, and rest, making it an excellent system to study SC biology.