The level of liver polyploidy was compared in three groups of humans: a young group aged 20–46, an older group aged 62–68 and the oldest group aged 70–79. The most important trend showed by the data was that there is a depletion of 2N and 4N cells, accompanied by an increase in 8N and 16N cells as a function of advancing age. There was a high degree of variability in the percentage of cells in each ploidy class from one individual to the next for all age groups. For this reason, polyploidy appears to be a less effective biomarker of aging in humans than it is in experimental animals.