Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
  1. Home
  2. Search

Refine search

Refine search

Access:
Content type:
Publication date:
Apply   From and To filters
Subject: Show more
Journals Show more
Publishers: Show more
Societies Show more
Series: Show more
Collections: Show more

Actions for selected content:

Select all | Deselect all
  • View selected items
  • Export citations
  • Download PDF (zip)
  • Save to Kindle
  • Save to Dropbox
  • Save to Google Drive

Save Search

You can save your searches here and later view and run them again in "My saved searches".

Please provide a title, maximum of 40 characters.
Cancel
×

2 results

  • Physiological and transcriptional status of genetically diverse perennial ryegrass (Lolium perenne L.) populations under drought stress

  • Gürkan Demirkol, Anıl Fırat Felek, Özlem Önal Aşcı, Nuri Yılmaz
  • Journal:
    Plant Genetic Resources / Volume 21 / Issue 4 / August 2023
    Published online by Cambridge University Press:
    06 November 2023, pp. 331-339
    • Article
      • You have access
    • PDF
    • HTML
    • Export citation

  • This study was designed to understand how drought stress impact on the physiological and molecular status of genetically diverse Lolium perenne L. (perennial ryegrass) populations. The sensitivities of the 36 perennial ryegrass populations were checked against PEG-6000-simulated drought stress by analysing physiological status. Afterward, drought-related gene expressions were evaluated under normal and stressed conditions. The drought stress significantly up-regulated the drought-related genes in P6, P10, P15 and P30, while no difference was observed in drought-sensitive ones. The results collectively showed that four populations (P6, P10, P15, P30) are tolerant to drought stress and activate drought-related genes. Genetic similarities of the populations were also monitored using microsatellite (SSR) markers. The ten SSR primers detected 38 alleles. Surprisingly, the drought-tolerant populations were classified into different groups by principal component (PCA) and cluster analysis, showing that they are genetically different. Moreover, four unique alleles were identified by two SSR primers (P-07, and P-08) in P6, P10 and P15. In addition, the drought-tolerant populations (P6, P10, P15, P30) can be used to develop new perennial ryegrass cultivars for areas having drought problems.

  • 19 - Brain imaging and pharmacogenetics in Alzheimer's disease and schizophrenia

  • from Part VI - Pharmacogenetics and brain imaging
    • By Steven G. Potkin, Department of Psychiatry and Human Behavior, University of California, Irvine, USA, James L. Kennedy, Clarke Institute of Psychiatry, University of Toronto, Canada, Vincenzo S. Basile, Clarke Institute of Psychiatry, University of Toronto, Canada
  • Edited by Bernard Lerer, Hadassah-Hebrew Medical Center, Jerusalem
  • Book:
    Pharmacogenetics of Psychotropic Drugs
    Published online:
    20 August 2009
    Print publication:
    29 August 2002, pp 391-400

  • Summary

    Brain imaging techniques combined with genetics contribute to developing an understanding of the pathophysiological mechanism of disease and treatment response. Psychiatric genetics identifies associations between allelic variation in genes and the risk for the development of psychiatric illness. Although the genetic association of apoE4 with the development of Alzheimer's disease is well established, there is a need to devise strategies that can fill in the missing links between apoE gene variation and the pathophysiological mechanism of Alzheimer's disease. Brain imaging addresses and bridges this gap. The combination of imaging, allelic characterization, and clinical response synergistically contributes to understanding the role apoE4 plays in the development of Alzheimer's disease and its response to treatment. An analogous argument is made for combining brain imaging with allelic subtyping to understand clinical antipsychotic response in schizophrenia. This chapter establishes the efficacy of new pharmacological treatments for groups of patients with schizophrenia and Alzheimer's disease.