The chapter begins with the observation that global history has an ambivalent attitude towards explanation. In many cases, the mere presentation of sources and voices from many different parts of the world seems sufficient to justify a global approach. The need for explanation is ignored or even denied. In other cases, global explanation is eagerly pursued, but often at the expense of more complex explanatory models that incorporate factors at different scales. In this perspective, global explanations are claimed to be inherently superior and a privileged way of explaining historical phenomena. After a cursory survey of current positions on causality and explanation in general methodology and ‘formal’ historical theory, the chapter proposes a brief typology of explanatory strategies. It goes on to discuss the peculiarities of explanation within a framework of connections across great distances and cultural boundaries. The much-exclaimed concept of narrative explanation is found to be of limited value, as it underestimates the difficulties of producing coherent narratives on a global scale. Concepts offered in the social science literature, such as the analysis of mechanisms and temporal sequences, could be helpful in refining purely narrative approaches to explanation.