Medicine teems with anecdotes, brief, pointed accounts of healthcare episodes, informed by observations and narrative arguments. Initially denoting hitherto undivulged, but notable, historical events, anecdotes narrated by doctors were not easily distinguishable from clinical cases. Those recounted by patients and carers in the modern era are the subject of this chapter, which investigates how they grasp, size up, and characterize human vulnerabilities, resulting from illness and inequalities in healthcare knowledge and power. An unregulated and anti-authoritarian idiom that does not seek to isolate events and experiences from subjective thoughts and feelings about them, these sorts of anecdotes can critically evaluate medical services and glimpse the truth about healthcare situations. Contemporary medicine, however, views anecdotal observations and viewpoints as biased and untrustworthy. Despite the current climate of scepticism concerning anecdotal information, anecdotes remain prolific oral and literary interventions, that provide vital insights into the interpersonal and social relations of healthcare.

The classical past, for Plutarch, offered a huge reservoir of history, art, and traditions, from which he drew examples of virtue for inspiration and encouragement. He expected that his readers should do the same. But he also insisted that the examples that we draw from that reservoir must be carefully strained and tested, using investigative acumen and skeptical discussion and evaluation, to remove the inevitable debris, the inescapable outcome of human ambition, competition, greed, and desire. Internecine war and personal rivalries polluted those great times even as they did his own day, and still do the present world. The best qualities of the classical past could be reacquired only by the constant exercise of prudent reason and controlled passion. Plutarch dared his readers to accept this challenge.

Johnson’s Lives of the Poets are a classic not only of literary criticism but of biography as well. Originally intended as brief prefaces in an anthology of fifty-eight poets from the seventeenth and eighteenth centuries, they increased in scope as Johnson worked on them, and as one commentator has said, they became “a book of wisdom and experience … a commentary on human destiny.” The lives of Milton, Swift, Dryden, and Pope are really books in their own right, and the earlier Life of Savage is a deeply felt account of someone Johnson knew well in his youth. He made good use of such documentary material as he was able to obtain, and for recent poets was able to draw upon his own memory of telling anecdotes. Above all, the Lives explore the range of human achievement, its failures and also its triumphs.

How are we to make truthful statements, depictions or communications about a changing world? A fact is not an actuality but a statement about actuality; data are not given but captured and communicated; communication modifies the actuality it describes. We have many tools at our disposal – journalistic and essayistic, photographic, scientific – with which to name and depict things that are too big, too small, too fast or too slow for human perception. This chapter suggests that they share two fundamental procedures: abstraction and anecdote. The former culls large-scale dynamics from massive collections of data; the latter seizes on unique instances of the confluence of forces. Can an investigation of truth-practices in stories, reports, diagrams and images give us tools to redirect the changes we know we are experiencing but for which the means of expression seem suddenly ineffectual?

People often find statistics confusing because anecdotes more effectively tell stories and no one’s direct experience matches the statistical realities. The younger any individual is introduced to any drug the higher the risk of developing dependence. This is especially true for marijuana because it affects neurodevelopment in early adolescence. However, Horwood has shown than the lifetime rate of marijuana dependence does not accurately portray the overall progression of use because the majority of those who ever become dependent discontinue or reduce use sufficiently to no longer meet the DSM criteria for Cannabis Use Disorder (CUD). While 43% of those with onset of marijuana use at 13 years old meet criteria for CUD at some time by age 30, only 15% are dependent during the previous year at 30. The generally accepted rate of CUD for those 12 and older who have ever used marijuana is approximately 9%, compared to a 15% dependence rate for alcohol. The more frequently individuals use marijuana, the more they use on each occasion. The increased rates of marijuana use in Conduct Disorder (CD), Antisocial Personality Disorder (ASPD) and Attention Deficit Hyperactivity Disorder (jsADHD) are discussed.