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A 34-year-old G3P2 at 20 weeks’ gestation presents to the A&E (E.R.) department of your tertiary care center with a three-hour history of nausea and vomiting associated with recurrent right upper quadrant pain, no longer alleviated by analgesics.
A 30-year-old primigravida with schizophrenia is referred by her primary care provider to your high-risk obstetrics unit at a tertiary center. Her mental illness is controlled by clozapine, and she takes routine prenatal vitamins. The patient is at 12+2 weeks’ gestation by dating sonography; first-trimester fetal anatomy was normal with a low risk of aneuploidy. Results of routine prenatal investigations are unremarkable. The patient does not have any obstetric complaints.
A 38-year-old primigravida is a recipient of a renal transplant. She is referred by her primary care provider for consultation and prenatal care of a spontaneous pregnancy at 10 weeks’ gestation by dating sonogram. She takes prenatal vitamins and has no obstetric complaints.
A 29-year-old primigravida is a recipient of a liver transplant. She is referred by her primary care provider to your high-risk obstetrics clinic for consultation and prenatal care of a spontaneous intrauterine singleton pregnancy at 12+0 weeks’ gestation by dating sonogram. The patient takes prenatal vitamins and has no obstetric complaints.
This chapter discusses congenital diaphragmatic hernia (CDH) from a perspective of antenatal management, including fetal intervention. It summarizes actual survival rates when this condition is managed after birth, essentially showing that there is no effective postnatal therapy in a subset of fetuses. Prediction methods are typically based on estimation of lung size by ultrasound and determination of liver herniation into the thorax. Three-dimensional (3D) ultrasound (US) and MRI both allow measurement of absolute lung volumetry. MRI allows better visualization of the ipsilateral lung than 3D US. Preliminary work on the use of diffusion-weighted imaging (DWI)-MRI as a tool to differentiate between normal and pathological lung development has shown a significant relationship between DWI-MRI parameters and gestational age in the normal fetus. The chapter also describes the current clinical experience with fetal surgery, including the design of trials that will have to determine the place of fetal surgery.
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