We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
This chapter reviews the relevant studies with human and animal cells aimed at the development of artificial gametes. During female gametogenesis (oogenesis), oogonia start the first meiotic division in the fetal period of life, but the process becomes arrested at a late prophase until puberty. Unlike oogenesis, male gametogenesis (spermatogenesis) is a continuous process in which spermatogonia enter meiosis and form primary spermatocytes. The chapter outlines the main methodological problems in artificial female and male gamete production, and suggests possible ways of their solution. As compared with mature oocytes, the use of germinal vesicle oocytes for somatic cell nucleus haploidization represents an even greater challenge because two steps of reduction are necessary. Experiments with the embryonic stem (ES) cells can help understand the mechanisms guiding the differentiation of stem cells towards the germline and thus prepare the route for the work with the adult stem (AS) cells.
Recommend this
Email your librarian or administrator to recommend adding this to your organisation's collection.