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1 results

  • Debate 40A - Should Primary Debulking Surgery be Performed for Metastatic Leiomyosarcoma?

  • from Section IV - Endometrial Cancer
  • Edited by Dennis S. Chi, Memorial Sloan-Kettering Cancer Center, New York, Nisha Lakhi, Richmond University Medical Center, Staten Island, Nicoletta Colombo, University of Milan-Bicocca
  • Book:
    50 Big Debates in Gynecologic Oncology
    Published online:
    20 July 2023
    Print publication:
    03 August 2023, pp 240-242

  • Summary

    Leiomyosarcomas (LMS) of the uterus are rare, aggressive malignancies with high rates of recurrence. Both uterine leiomyoma and LMS share common presenting symptoms; because of this, the diagnosis of uterine LMS is commonly made upon pathology evaluation after myomectomy or hysterectomy for suspected benign disease. Uterine LMS commonly expresses estrogen (ER) and progesterone (PR) receptors. However, the role of oophorectomy in premenopausal women with uterine LMS remains controversial. Based on the current literature, there appears to be no added benefit of removing bilateral ovaries following the diagnosis of early stage uterine LMS in premenopausal women. In addition, there remains minimal data demonstrating any increased risk of recurrence or tumor growth following ovarian preservation in this patient population. If the ovaries are preserved, close long-term follow-up is important.