The paper investigates to what extent the knowledge accumulated in the field of Bio-Inspired Design might benefit the process of biologicalisation in manufacturing. According to visions making inroads in the manufacturing field, the latter will not be limited to the consideration and the analysis of biological principles as a source of inspiration for solving technical and organizational problems. In fact, the process of biologicalisation in manufacturing foresees the development of bio-integrated and bio-intelligent systems. In light of these expected developments, Bio-Inspired Design’s might fail to support the whole transition to take place in the manufacturing field. Methodological limitations still to overcome represent an important barrier in this perspective too. While a transfer of knowledge from the design to the manufacturing domain seems unlikely, the authors individuate aspects that encourage cross-fertilization between Bio-Inspired Design and biologicalisation in manufacturing. These include the need to include biologists in engineering teams, the objective of sustainable development, and a shared attention to the evolution of (Design for) Additive Manufacturing.