Stratigraphic analysis of alluvial/colluvial sequences and 14C dating have been used as proxies for Holocene climate changes in the highlands of Tigray (northern Ethiopia). The studied records show alternations of buried soils and peaty–clayey sediments, pointing to wet, stabilization phases, and organic-free colluvium layers resulting from the abrupt occurrence of dry-climate episodes. The 14C dates, mostly unpublished, cluster in the 11,090–9915, 9465–9135, 8450–7330, 6720–3635, 2710–2345, and 1265–790 cal yr B.P. time spans. Evidence of subsequent pedogenesis is lacking in the area, apart from a buried humified horizon dated at 300 ± 60 14C yr B.P. (460–295 cal yr B.P.). Both the timing and the pattern of Tigray paleoclimatic events fit the corresponding framework, based on lake level changes, previously implemented for the Main Rift Valley. These findings give further support for arguing that the forcing mechanisms of the wet/dry fluctuations during the Holocene were effective over a large scale.