Greenhouse and field experiments were conducted at the Lacombe Research Station to evaluate mixtures of sethoxydim and fluazifop on green foxtail, wild oat, wheat, and barley in canola. In both environments the two herbicides interacted on the grass species in a synergistic manner. Many of the observed responses to mixtures of sethoxydim and fluazifop were 100% greater than those expected assuming an additive interaction between the herbicides. Mixtures with at least 80 g ha-1 of sethoxydim and 80 g ha-1 of fluazifop controlled more than 90% of green foxtail, wild oat, wheat, and barley under field conditions. These experiments indicate that the sethoxydim/fluazifop mixture is both complementary and synergistic. The mixture may allow reduced herbicide application rates and therefore reduced herbicide costs and less potential for negative environmental impact.