It is commonly held that even where questionnaire response is poor, correlational studies are affected only by loss of degrees of freedom or precision. We show that this supposition is not true. If the decision to respond is correlated with a substantive variable of interest, then regression or analysis of variance methods based upon the questionnaire results may be adversely affected by self-selection bias. Moreover such bias may arise even where response is 100%. The problem in both cases arises where selection information is passed to the score indirectly via the disturbance or individual effects, rather than entirely via the observable explanatory variables. We suggest tests for the ensuing self-selection bias and possible ways of handling the ensuing problems of inference.