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cephalosporine

European Journal of Anaesthesiology (1)

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A massive intrathecal cefazoline overdose
E. W. Lang, D. Weinert, A. Behnke, K. Pflug-Rolfes, M. Rautenberg
Journal:

European Journal of Anaesthesiology / Volume 16 / Issue 3 / March 1999

Published online by Cambridge University Press:

16 August 2006, pp. 204-205

Print publication:

March 1999
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This case report describes the clinical course of a patient who inadvertently received a massive intrathecal cefazoline overdose through a lumbar drain, which had been placed after trans-sphenoidal surgery for a pituitary adenoma. She received high-dose barbiturate therapy and was monitored with electroencephalography (EEG), somatosensory evoked potentials (SSEP), brainstem auditory evoked potentials (BAEP) and transcranial Doppler ultrasound (TCD). No cerebrospinal fluid (CSF) exchange was performed, but CSF was drained continuously with daily CSF-cefazoline level monitoring. Despite the extremely toxic dose, the patient soon recovered completely.