A new species of Cephalaria, C. bigazzii Bacch., Brullo & Giusso (Dipsacaceae), is described and illustrated. It is a typical chasmophyte, exclusive to a small area of SW Sardinia where it grows together with several other rare endemics. It belongs to the Cephalaria squamiflora group, showing close relationships with C. mediterranea and C. balearica. Its ecology, distribution and conservation status are examined. A distribution map of the new species and related species is provided. A new status and combination is proposed for Cephalaria ebusitana.