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1 results

  • 13 - Circadian Rhythms and Cardiac Function

  • Edited by Laura K. Fonken, University of Texas, Austin, Randy J. Nelson, West Virginia University
  • Book:
    Biological Implications of Circadian Disruption
    Published online:
    07 October 2023
    Print publication:
    12 October 2023, pp 285-309

  • Summary

    Circadian clocks in all tissues confer temporal organization to the physiology and behavior of organisms. Rhythms of the cardiovascular system have been scrutinized because of the morning peak of adverse cardiovascular events and because night and rotating shift work have been associated with heart disease and biomarkers of elevated cardiometabolic risk. Animal models support the important role that the clock plays in the heart. External disruptions such as jetlag and internal disruptions such as loss of clock function contribute to poor heart health. In this chapter, we review key findings from animal models of circadian disruption and from experiments in humans designed to isolate the effects of the circadian clock on cardiovascular physiology.