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1 results

  • Dynamics of proteins in solution

  • Marco Grimaldo, Felix Roosen-Runge, Fajun Zhang, Frank Schreiber, Tilo Seydel
  • Journal:
    Quarterly Reviews of Biophysics / Volume 52 / 2019
    Published online by Cambridge University Press:
    13 June 2019, e7
    • Article
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  • The dynamics of proteins in solution includes a variety of processes, such as backbone and side-chain fluctuations, interdomain motions, as well as global rotational and translational (i.e. center of mass) diffusion. Since protein dynamics is related to protein function and essential transport processes, a detailed mechanistic understanding and monitoring of protein dynamics in solution is highly desirable. The hierarchical character of protein dynamics requires experimental tools addressing a broad range of time- and length scales. We discuss how different techniques contribute to a comprehensive picture of protein dynamics, and focus in particular on results from neutron spectroscopy. We outline the underlying principles and review available instrumentation as well as related analysis frameworks.