Jointed goatgrass is a serious weed in winter wheat, and presently no herbicides are available for its selective control. This study examined the effect of time of emergence and removal on jointed goatgrass interference in winter wheat, as well as its rate of development and soil water extraction. The goal of this study was to suggest cultural practices that minimize jointed goatgrass interference in winter wheat. Jointed goatgrass development was identical to ‘Vona’ winter wheat in two crop seasons, even though precipitation differed drastically between seasons. Depth of soil water extraction of both species was also similar. Jointed goatgrass at 18 plants m−2 reduced grain yield 27 and 17% when emerging 0 and 42 d after Vona, respectively. The relationship between time of jointed goatgrass emergence after winter wheat and grain yield loss was Y = 30.6–0.29X (X = days, r = 0.72), indicating that plants emerging in late fall still caused yield loss. Removing jointed goatgrass by early March prevented winter wheat grain yield loss. The interference data suggests that producers assess infestation levels and plan control measures in early March.