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This chapter discusses several twin-specific factors that could affect handedness in twins and thereby decrease concordance rates in twins. The classical method to determine the genetic contribution to a trait is to compare concordance for that trait between monozygotic (identical) and dizygotic (fraternal) twins. The chapter also discusses which implications the model of inheritance for handedness has on concordance rates in twins. It investigates the effect of special twin factors, such as perinatal trauma and mirror-imaging on concordance rates in twins. Understanding the role of these factors in twins will help to interpret the results of twins studies and may resolve part of the controversy about genetic aspects of handedness and language lateralization. An explanation for the low concordance for handedness and lateralization in twin pairs could be the presence of a non-genetic factor that affects twins more than singletons.
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