The information potential of human skeletal remains—as for any excavated material—is impacted by the conditions of archaeological burial, and the environments and actions experienced during subsequent excavation, laboratory processing, study, and storage. A conservation approach emphasizes the mitigation of threats to material stability and integrity, which for excavated collections are often most critical at the point of archaeological exposure and recovery. Conservation techniques involving application of modern synthetic materials for stabilizing skeletal remains in the field are discussed, using case examples primarily from terrestrial archaeological projects in Mesoamerica. The potential effects of the use of various conservation materials on results of biomolecular instrumental analysis are included.