We prove a contact non-squeezing phenomenon on homotopy spheres that are fillable by Liouville domains with large symplectic homology: there exists a smoothly embedded ball in such a sphere that cannot be made arbitrarily small by a contact isotopy. These homotopy spheres include examples that are diffeomorphic to standard spheres and whose contact structures are homotopic to standard contact structures. As the main tool, we construct a new version of symplectic homology, called selective symplectic homology, that is associated to a Liouville domain and an open subset of its boundary. The selective symplectic homology is obtained as the direct limit of Floer homology groups for Hamiltonians whose slopes tend to $+\infty$ on the open subset but remain close to $0$ and positive on the rest of the boundary.