This meta-analytic study aims to assess the relationship between innovation and organizational performance. Examining studies published from 2012 to 2021 using a specific protocol resulted in selecting 180 effect sizes from 143 studies. Comprehensive Meta-Analysis Software (CMA2) (2.2.064) software facilitated data analysis. Findings reveal a positive and significant relationship between innovation and organizational performance. Moderating analysis identifies country, continent, year of publication, and innovation type as moderating variables. Additionally, recent years exhibit a noteworthy convergence in the relationship trend between innovation and organizational performance. Enhancing organizational performance remains a critical concern. The study’s outcomes offer valuable insights for managers, especially in international organizations to improve the planning and management of innovation and performance in their various branches and projects in different continents and countries.