Two indigenous chicken breeds: naked neck (N) and local white (W) feathered chicken called Netch as sire lines and two exotic chicken breeds: Fayoumi (F) and Rhode Island Red (R) as dam lines were crossed with the objective of producing 4-way cross-bred chicken population, which will later be used as base population to produce synthetic chickens. They were tested under on-station conditions in a college farm and under on-farm conditions at several typical village farms. Mortality during brooding period was lower under on-farm than on-station conditions, which may be owing to housing of the chicks in hay box-brooder on-farm and the coccidiosis infection on-station. However, higher on-farm mortality was observed during the laying period than on-station; mainly because of predation. There was a significant difference between the two systems in recorded body weight from early age to maturity. Age at first egg was lower on-farm than on-station. Average number of eggs produced was not significantly different; although chickens on-station laid more eggs than those on-farm. Hen-housed egg production was lower on-farm than on-station owing to higher mortality in the on-farm system.